akinks wrote:Is there any way he could use a balanced (or pseudo balanced) connection between guitar & amp to help reduce the interference?
That assumes that most of the interference is being picked up through the cable - you could test this by running a very short cable first I suppose.
To balance/debalance the guitar signal you could use a couple of passive DI boxes and reverse the one on the other end. Not sure it would help much though if you consider what the guitar pickups are doing.