I will second/third/whatever Chris Ware stuff. Daniel 'ghost world' Clowes is a bit hit miss for me but his recent ICE HAVEN was an absolute treat.
I have tried so so many times to bring my favourite comic to the attention of this board but to no avail.
100 Bullets. It really is my favourite comic of all time. Written by a Chicago native Brian Azzarello, and often featuring more 'indie' landmarks and places of the city itself. It's not restricted to just that though, and his partner Eduardo Risso's artwork is so good that it takes a fair few reads to actually notice it's greatness. Rarely fancy, always superb.
It's tone lies somewhere between on-form Batman (sans the costumes) and the Usual Suspects. Or something like that anyway. In fact, Azzarello and Risso did do a Batman story called Broken City which was also great.
It is still running at the moment. I think it is up to issue 72 out of a pre-planned 100. I usually wait for the collections to come out, of which there are 9 i think at the moment. Also, it's nice and easy to come by being that is published by DC/Vertigo.
I love the way it was pitched as a 100 issue run, with the whole plot already mapped out in their heads (minus a few details i imagine).
If anyone buys it, reads it, and then really hates it, i will give you your money back. It really is bloody marvellous.