I have two:

The way Madeline Kahn says, "God damn it" as Harvey Korman interrupts her when she's seducing Cleavon Little in Blazing Saddles.

and

Raymond J. Barry's working of the line, "That was not your right" just before he gets killed by Goran Visnjic in The Deep End.

Drug delivery man to an actor fellow in "Bringin' you the drugs 4"

"Hello sir here is your line...of coke"

fucking PM me for more awesome jokes. my pants are full. of jokes.

Most of Withnail & I would go in this category.

Some highlights are:

Withnail: I feel like a pig shat in my head.

Withnail: We want the finest wines available to humanity. And we want them here, and we want them now!

Withnail: I must have some booze. I demand to have some booze.

Irishman: I called him a ponce. And now I'm calling you one, PONCE!

Withnail: Scrubbers!

Silence of the Lambs - "Buffalo Bill" Gumb when agent Starling asks him if he knew Frederica. "No, nuh-uh. Oh wait... was she a great big fat person?"

Not to mention the whole "lotion in the basket" exchange. One of the best creepy bad guy performances ever.

"Dolores, go home!"

--Grease 2

The best "what the fuck" in a movie is in So I Married an Axe Murderer. Other than that, the movie sucked/.

"you don't scare me! work on it."

"you're the kind guy who'd fuck another guy in the ass without the common courtesy to give him a reach around. i'll be watching you."

"fuckabees."

Slap Shot:
1:"Well, what did he say?"
2:"OWWNS, OWWNS"

"when a man sticks a gun in your face, you got two options; you can die, or you can kill the mother fucker!"

Christopher J. McGarvey wrote:Irishman: I called him a ponce. And now I'm calling you one, PONCE!

Yeah, it's awesome.